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The cascade of intracellular reactions triggered as a result leads to a decrease in the production of hunger-stimulating neuropeptides (specifically, neuropeptide Y) and, as a result, a relatively higher level of neuropeptides stimulating satiety

3 Side effects typically improve over time with both medications

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This triple mechanism distinguishes it from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist)

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Because the article says people who have had their gallbladder removed already face higher long-term rates of bile acid diarrhea, and semaglutide commonly causes diarrhea of its own